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Zyban is used for smokers who are addicted to cigarettes quit smoking, they may suffer from symptoms that can be psychological, emotional, or physical in nature. This is called withdrawal. They may experience irritability, anxiety, difficulty concentrating, restlessness, or depression. Zyban is the first nicotine-free pill to help you quit smoking. A prescription medicine available only from your healthcare professional, Zyban has helped many smokers, even those who have smoked 10 years or more, put down their cigarettes.